There are hundreds of ways that chronic pain, DNA damage, aging ,
oxidative stress, inflammation , antioxidants, metabolism and
immune systems are related . A logical place to start checking out
those connections is the link between the management of oxidative
stress and the avoidance or at least later development of many
degenerative and often painful conditions that we expect to be a
part of normal aging. Oxidative stress is a killer - even though it
doesn't sound serious and it is also linked to many conditions and
diseases like Parkinson's and Alzheimer's disease , myocardial
infarction (a heart attack that blocks the blood supply to a part
of the heart muscle causing it to die ) other causes of heart
failure and chronic fatigue syndrome. Oxidative stress is what
happens when there is either an out of control increase in
peroxides and oxy-radicals/free radicals (collectively known as
reactive oxygen species) or a big shortage in the body's
antioxidant resources , one of which is l-glutathione . When the
human body isn't able to successfully use its supply of
antioxidants to protect itself- at a cellular level- from free
radical damage, you end up with oxidative stress. Reactive
oxidative species (ROS) come from different sources externally or
internally . Externally, free radicals are the result of ;
ingested/inhaled pathogens, toxins , cigarette smoke ,
environmental pollutants , chemo , the sun , radiation, vigorous
workouts and good old stress . Internally, peroxides and other free
radicals are a normal product of metabolized oxygen . Actually, the
immune system use oxy-radicals to attack bacteria, toxins and other
invaders . Normally , our own antioxidant reserves will remove
these internally produced free radicals . But , if age and/or weak
health and lousy diet interfere with our natural ability to prevent
oxidative stress the damage accumulates and our systems are
eventually overwhelmed . When you think of antioxidants - think
antiaging Oxidative stress and reactive oxygen species free
radicals are also responsible for DNA damage and that in turn can
lead to cell death or mutation. Typically , just as our production
of antioxidants like glutathione declines with age, (and you can't
take an oral glutathione supplement [1] ) so also does our usual
ability to keep our DNA in good repair . One obvious illustration
of the destruction caused by oxidative stress is the wrinkled look
of the skin of sun worshippers . According to the Free Radical
Theory of Aging, the accumulation of dead cells caused by the
unchecked action of oxy-radicals is a key contributor to the
process of aging and although we cannot stop that , no one will
debate that good health practices can deliver a increased quality
of life through what should be the golden years. [1]
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