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Researchers at the University of Texas Southwestern Medical Center, Dallas used microarray analysis to compare miRNA expression patterns of primary rat cardiomyocytes with different levels of myocardin-related transcription factors (MRTFs). MRTFs associate with serum response factor (SRF) to drive the expression of actin and other cytoskeletal protein genes. miR-145 and miR-143 were among the most [...]

BOULDER, Colo.–(BUSINESS WIRE)–miRagen Therapeutics, Inc., a biopharmaceutical company focused on improving patients’ lives by developing innovative microRNA-based therapeutics for cardiovascular and muscle disease, announced today it had received the Colorado BioScience Association’s 2009 Rising Star of the Year Award. The award, which recognizes a Colorado life sciences company that has demonstrated it is “one to [...]

miRecords is resource for animal miRNA-target interactions developed at the University of Minnesota. miRecords consists of two components. The Validated Targets component is a large, high-quality database of experimentally validated miRNA targets resulting from meticulous literature curation. The Predicted Targets component of miRecords is an integration of predicted miRNA targets produced by 11 established miRNA [...]

11/12/09 – CAMBRIDGE, Mass.–( Business Wire)–Alnylam Pharmaceuticals, Inc. an RNAi therapeutics company, today announced that it will webcast its upcoming R&D Day live on the “Investors” section of the company’s website at www.alnylam.com. Alnylam’s R&D Day will be held on Thursday, November 12, 2009 from 8:30 a.m. to 12:00 p.m. ET Alnylam scientists and management will [...]

Researchers at the LSU Neuroscience Center have discovered a role for miRNA-146a in the evasion of Herpes simplex virus type-1 (HSV-1) from the complement system (a major first-line host defense mechanism), and the activation of key elements of the arachidonic acid cascade known to contribute to Alzheimer-type neuropathological change. MicroRNA microarray revealed that human primary neural cells [...]

Researchers at Heidelberg University used a combination of expression profiling of miRNAs and subsequent functional inhibitory screening in primary hippocampal neurons to identify miRNAs in the synaptodendritic compartment that function during synaptic development. MicroRNA microarrays identified ten mature miRNAs that were enriched and four mature miRNAs that were strongly depleted in synaptosomes compared with whole [...]

A review of microRNA studies provides an overview of the evidence available to date which support the pathogenic role of miRNAs in human genetic diseases and describes the results of recent studies indicating the phenotypic consequences of miRNA alterations on the function of several tissues and organs. These studies suggest that the spectrum of genetic [...]

AiRNA Pharmaceuticals Allergan Alnylam Pharmaceuticals Benitec BioCandell Therapeutics Calando Pharmaceuticals Cenix BioScience Cequent Pharmaceuticals Copernicus Therapeutics Dicerna Pharmaceuticals Expression Genetics Corporation General Research Laboratory Intradigm Corporation MDRNA Mirna Therapeutics MiRagen Therapeutics Nitto Denko Technical Corp Opko Health Oxford BioMedica Polyplus Transfection Quark Pharmaceuticals Regulus Therapeutics RXi Therapeutics Santaris Pharma Senesco Technologies Silence Therapeutics Siranoamics siRNAsense A/S Sylentis Pharmaceuticals Tacere Therapeutics Targeted Genetics Corporation Tekmira Pharmaceuticals Corporation

Thanks go to our reader Qinghua Jiang who pointed out a data base called miR2Disease. This collaboration project between the Harbin Institute of Technology (HIT) and the Center of Computational Biology and Bioinformatics at the Indiana University of Medical School is a manually curated microRNA-disease database focusing on miRNA deregulation in various human diseases. The current [...]

Heart disease and cancer represent the number one and number two killer diseases in developed countries. Identifying biomarkers to detect these and other diseases at early stages remains an important research goal and researchers are scrambling for ways to identify contributing factors to the pathogenesis of diseased cells in the body.  In recent years, research [...]