Feed: microRNA Blog - AggScore: 65.1

miRviewer: A multispecies microRNA homologous viewer

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In order to better understand microRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. The miRviewer web-server encompasses all known (and some novel) microRNAs of currently fully annotated animal genomes in a visual ‘birds-eye’ view representation. miRviewer provides a graphical outlook of the current microRNA world together [...] Related posts:

1. miRNAkey – A software pipeline for the analysis of microRNA Deep Sequencing data

Regulus Announces New Publication Showing Potential Therapeutic Benefit of Targeting microRNA-21 in Fibrosis

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-New study published in Science Translational Medicine demonstrates microRNA-21 contributes to fibrogenesis in the kidney -Regulus, in partnership with Sanofi, developing novel anti-fibrotic therapies targeting microRNAs B.N. Chau et al. “MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways” Sci Transl Med 15 February 2012: Vol. 4, Issue 121, p. 121ra18 Sci. Transl. Med. [...] Related posts:

1. Regulus Therapeutics to Present New In Vivo Data for microRNA-21 in Kidney Fibrosis
2. Regulus Therapeutics Initiates an Orphan and Rare Disease microRNA Therapeutic Effort in Brain Cancer
3. Regulus Strengthens Patent Coverage of miR-122

miR-375 a potential prognostic marker of head and neck cancers

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Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas. Researchers at Department of Pathology, Albert Einstein College of Medicine used global miRNA expression profiling of head and neck squamous cell carcinoma (HNSCC) samples and adjacent normal tissue to rank those miRNAs that [...] Related posts:

1. MicroRNA Profiling and Head and Neck Cancer
2. Study Shows Potential for microRNAs to Predict Gastric Cancer Recurrence
3. MiraDx Highlights Breakthrough Publication Describing a Marker for Resistance to Platinum Treatment in Ovarian Cancer

miRdSNP: a database of disease-associated SNPs and microRNA target sites on 3′UTRs of human genes

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Single nucleotide polymorphisms (SNPs) can lead to the susceptibility and onset of diseases through their effects on gene expression at the posttranscriptional level. Recent findings indicate that SNPs could create, destroy, or modify the efficiency of miRNA binding to the 3′UTR of a gene, resulting in gene dysregulation. With the rapidly growing number of published [...] Related posts:

1. mirSVR scoring for predicted microRNA target sites
2. miR2Disease Database
3. starBase: a database for exploring microRNA–mRNA interaction maps

Marina Biotech Receives Notice of Acceptance for Patent Broadly Covering Its Unlocked Nucleobase Analog (UNA) Technology

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Patent Protects Use of UNAs in Multiple Nucleic Acid Constructs Including siRNAs, microRNA Mimics, Antagomirs and Single-Stranded Constructs BOTHELL, WA–(Marketwire – Jan 23, 2012) – Marina Biotech, Inc. (NASDAQ: MRNAD), a leading oligonucleotide-based drug discovery and development company today announced that the Intellectual Property Office of New Zealand (IPONZ) has issued a Notice of Acceptance [...] Related posts:

1. Marina Biotech Announces Allowance of Patent Covering DiLA2 Delivery of microRNAs
2. Marina Biotech Describes Integrated Technology Platform for the Development of RNAi-, microRNA- and Antisense-based Therapeutics
3. Regulus, Alnylam and Isis Announce U.S. Allowance of Tuschl III Patent Application Covering miR-21

Rosetta Green Has Successfully Improved Plant Growth Under Intermittent Irrigation With Seawater

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The experiment tested a specific microRNA gene that was identified in corn and soybean, and confirmed the potential to develop plants capable of withstanding intermittent irrigation with seawater and growth in high salinity soils During the experiment, plants were intermittently irrigated with salt water with three times the salinity level of seawater Rosetta Green has [...] Related posts:

1. Rosetta Genomics Announces the Availability of Improved Tumor Classification Diagnostic
2. Rosetta Genomics to Present at the 2009 Maxim Group Growth Conference
3. Researchers Make a Case for Green Tea Treatment

Silence Therapeutics Signs Collaboration with miRagen Therapeutics to Evaluate Delivery of Novel microRNA-based Therapeutics

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LONDON, January 9, 2012/PRNewswire-FirstCall/ – - Third collaboration to investigate the potential application of Silence’s proprietary RNAi delivery technologies in the development of novel microRNA-based therapeutics Silence Therapeutics plc (AIM: SLN) (“Silence”), a leading RNA interference (RNAi) therapeutics company, announces that it has signed an agreement with miRagen Therapeutics, Inc. (“miRagen”), to assess the delivery [...] Related posts:

1. Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics
2. RXi Pharmaceuticals and miRagen Therapeutics Announce Formation of Research Collaboration in the Field of microRNA
3. miRagen Therapeutics Named University of Colorado Technology Transfer Office Bioscience Company of the Year

RNA Interference – Video Animation

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This is an amazing video animation from Nature Reviews Genetics! This animation introduces the principles of RNAi involving small interfering RNAs (siRNAs) and microRNAs (miRNAs). It takes you on an audio-visual journey through the steps of gene expression and shows you an up-to-date view of how RNAi can silence specific mRNAs in the cytoplasm. There [...] Related posts:

1. Nice microRNA Video
2. Upcoming European microRNA Conferences
3. RNAi, miRNA and siRNA Conference – London

Hepatitis C virus hijacks liver microRNA

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Stabilization of hepatitis C virus RNA by an Ago2–miR-122 complex MicroRNAs regulate eukaryotic gene expression by binding to regions of imperfect complementarity in mRNAs, typically in the 3′ UTR, recruiting an Argonaute (Ago) protein complex that usually results in translational repression or destabilization of the target RNA. The translation and decay of mRNAs are closely [...] Related posts:

1. First microRNA Targeted Drug Reaches Phase II Clinical Trial
2. New Publication – microRNA in Fatty Liver Disease
3. Mayo Clinic Health Letter Highlights – July

Regulus Therapeutics Initiates an Orphan and Rare Disease microRNA Therapeutic Effort in Brain Cancer

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-Regulus, Accelerate Brain Cancer Cure (ABC2) and Samsung Medical Center to Advance microRNA Therapeutics for Glioblastoma - LA JOLLA, Calif., Dec. 12, 2011 /PRNewswire/ – Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced the initiation of a new discovery effort in microRNA therapeutics for the treatment [...] Related posts:

1. Regulus Announces New Publication Showing Potential Therapeutic Benefit of Targeting microRNA-21 in Fibrosis
2. Alnylam Pharmaceuticals & Regulus Therapeutics in the News
3. Regulus Therapeutics to Present New In Vivo Data for microRNA-21 in Kidney Fibrosis